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It is found in chocolate, as well as in a number of other foods, including the leaves of the tea plant, and the kola nut.It is classified as a xanthine alkaloid, others of which include theophylline and caffeine. Theophylline is chemically similar to theobromine (found in chocolate) and caffeine. Talk to your doctor about the possible risks of using this drug for your baby's condition. Some of these interactions still are unconfirmed. Drug information provided by: IBM Micromedex. It is the world's most widely consumed psychoactive drug. Theophylline is a drug used in combination with other medications for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Theobromine, formerly known as xantheose, is a bitter alkaloid of the cacao plant, with the chemical formula C 7 H 8 N 4 O 2. Nainar et al Trop J Pharm Res, April 2012;11 (2): 323 Estimation of IVIVC using the biopharmaceutical drug classification system BCS is a fundamental guideline for determining the conditions under which in- ... Theophylline f2 test Wagner-Nelson Theophylline is a dimethylxanthine having the two methyl groups located at positions 1 and 3. theophylline monohydrate quibron lasma theoclear l.a.-260 elixophyllin theolair theobid jr. quibron-t/sr theolixir slo-phyllin nuelin theovent theochron aerolate jr respbid accurbron theophylline theophylline melting point standard theobid theo-24 elixicon theocin duraphyl theo-dur theophylline-sr aquaphyllin elixophyllin sr theacitin unifyl These drugs are airway dilators, opening the bronchial tubes. Keep all appointments for testing the blood level. Theophylline decreases the effects of lithium, pancuronium, and propofol. Drug information provided by: IBM Micromedex. Overview of Theophylline for Dogs and Cats; Theophylline, also known as Theo-Dur®, belongs to the class of drugs known as smooth muscle relaxants, affecting the respiratory muscles in dogs and cats. Pregnancy and breastfeeding safety information are provided. Drug-food. Bronchodilators are drugs that open the airways of the lungs. Yet, respective clinical implications are currently unclear, particularly for preterm neonates. DRUG INTERACTIONS. It is structurally similar to caffeine and is found in green and black tea. They treat asthma, COPD, allergies, and other breathing problems. If not, monitor theophylline levels and adjust dosage as needed. Theophylline is used to treat lung diseases such as asthma and COPD (bronchitis, emphysema). In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Drugs that may either increase or decrease the levels of theophylline include: isoniazid and furosemide. A relative absence of IL-10 characterizes the asthmatic airways and may contribute to the development and severity of allergic inflammation. The interaction may be pharmacodynamic, i.e., alterations in the therapeutic response to theophylline or another drug or occurrence of adverse effects without a change in serum theophylline concentration. Theophylline belongs to a class of medications called bronchodilators, used in treating asthma and other airway diseases. Induction of IL-10 production by theophylline may therefore mitigate inflammation and contribute to the clinical efficacy of this class of medications. The molecular mechanism for the anti-inflammatory action of theophylline is currently unknown, but low-dose theophylline is an effective add-on therapy to corticosteroids in controlling asthma. Unlike many other psychoactive substances, it is legal and unregulated in nearly all parts of the world. Theophylline belongs to a group of medicines known as bronchodilators. The plasma-theophylline concentration is decreased in smokers, and by alcohol consumption. theophylline is a topic covered in the Davis's Drug Guide. Schedule your appointment now for safe in-person care. Coadmininstration with drugs that decrease theophylline clearance (eg, cimetidine, ciprofloxacin, and erythromycin and other macrolides): 0.2-0.3 mg/kg/hr IV or PO (extended release) q12-24hr Congestive heart failure: 0.39 mg/kg/hr IV for next 12 hours after loading dose, then 0.08-0.16 mg/kg/hr This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Davis Drug … Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. This medication belongs to a class of drugs known as xanthines. It works alongside your preventer inhaler to reduce your risk of an asthma attack. Theophylline is sometimes used to treat breathing problems in premature infants. Theophylline is also used in hospital emergencies. It works by relaxing the muscle around the airways in the lungs. What is the class of drug of It has a role as a vasodilator agent, a bronchodilator agent, a muscle relaxant, an EC 3.1.4. Monitor theophylline response and serum levels; dosage adjustment may be needed. Although recognized as overly conservative, metoprolol is currently the common low/high BCS permeability class boundary reference compound, while labetalol was suggested as a potential alternative. Find everything you need to know about Theophylline (Theo-24), including what it is used for, warnings, reviews, side effects, and interactions. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes. Don't delay your care at Mayo Clinic. What is the indication for theophylline? Differences in the half-life of theophylline are important because the … When you take theophylline at home it’s usually as a tablet or capsule that lasts all day. There are several known mechanisms of action to explain the effects of caffeine. Aims: Evidence suggests that the rate of oral drug absorption changes during early childhood. Find information on Theophylline (Elixophyllin, Theo-24) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Theophylline Accession Number DB00277 Description. A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. What is the MOA for theophylline? View Notes - CC Test 1 Drugs from NURSING 4551 at University of the Incarnate Word. Common side effects include cough, headaches, vomiting, nausea, and diarrhea. Theophylline interacts with a wide variety of drugs. ... After you or your child begin taking theophylline, it is very important that your doctor check the level of the medicine in the blood at regular intervals to decide if the dose needs to be changed. To view the entire topic, please sign in or purchase a subscription. Drug class: Methylxanthines See Prices Note: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Caffeine is a central nervous system (CNS) stimulant of the methylxanthine class. It helps manage day-to-day asthma symptoms by keeping your airways open and making breathing easier. Inhaled corticosteroids are the preferred asthma maintenance treatment during pregnancy due to the potential toxicities of theophylline and the propensity for drug interactions that can reduce theophylline clearance. Corticosteroids act, at least in part, by recruitment of histone deacetylases (HDACs) to the site of active inflammatory gene transcription. Interaction between a vaccine and a drug has been reported only with influenza vaccine and four drugs (aminopyrine, phenytoin sodium, theophylline, and warfarin sodium), and with BCG vaccine and theophylline. Advise patient to take drug on an empty stomach. This is a decision you and your doctor will make. Concurrent use with ephedrine, isoproterenol, and halothane may increase the risk of cardiac side effects. The Washington Manual of Medical Therapeutics helps you diagnose and treat hundreds of medical conditions. Consult clinical recommendations from a resource that has been trusted on the wards for 50+ years. The underlying mechanism of the interacti … Drug-lifestyle. theophylline [the-of€´ĭ-lin] an alkaloid derived from tea or produced synthetically; it is a smooth muscle relaxant used chiefly for its bronchodilator effect in the treatment of chronic obstructive pulmonary disease, emphysema, bronchial asthma, chronic bronchitis, and bronchospastic distress. Any food: Accelerates absorption. Delivered either orally or intravenously, theophylline acts as a bronchodilator to reduce airway reactivity that leads to wheezing and shortness of breath. The plasma-theophylline concentration is increased in heart failure, hepatic impairment, and in viral infections. Bronchodilators are medicines that relax the muscles in the bronchial tubes (air passages) of the lungs. There are 3 types of bronchodilators used to treat asthma. Theophylline derivativesThese agents directly relax smooth muscles of bronchial airways and pulmonary blood vessels, acting as bronchodilators and smooth muscle relaxants. 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